Chronic Pancreatitis - Recurrent Acute Pancreatitis (Adults)
Research Workgroup
CP-RAP ADULT
Name:
Name:
Purpose:
Research working groups are a valuable platform for scientists with common research interests to collaborate and share knowledge.
These groups consist of staff members from various institutes and centers assembled by the consortium Steering Committee leadership. They provide input from their respective perspectives. Co-chairs, typically institute or center directors or senior staff, lead these working groups with the authority to approve major activities and funding actions.
These working groups are crucial in advancing scientific research, fostering collaboration, and promoting innovation across various fields of cancer research.
Objective:
The Adult CP Working Group of the Consortium for the Study Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)29 was tasked by its Steering Committee to design a longitudinal study of CP, which led to the conception and development of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies (PROCEED). In addition to addressing the primary objectives of the CPDPC, PROCEED will provide a platform for multiple translational and mechanistic studies.
Hypothesis and Objectives
The overarching goal of PROCEED is prospective ascertainment and follow-up of a well-phenotyped study population at different stages of CP to accurately define its progression and associated complications. Furthermore, collection of biological samples from study subjects at predefined intervals will provide a platform to develop biomarkers of early diagnosis and prediction of disease progression, understand disease mechanisms, and discover genetic and other factors affecting susceptibility and progression.
PROCEED has four primary objectives – to:
1. Establish a model longitudinal research cohort of adult subjects for the study of CP and its complications.
2. Estimate the risk of progression from suspected to definite CP, and the risk of new-onset diabetes or exocrine pancreatic dysfunction in definite CP, and study how the risks are influenced by patient characteristics and conditions.
3. Test the predictive capability of candidate biomarkers for the diagnosis and prognosis of CP.
4. Develop a platform for conducting biomarker, genetic, and mechanistic studies using clinical information and longitudinal biospecimens.
Savtiri Appana, MS
Member Organization
Member Type/Role/Title
