Diabetes Mellitus - Chronic Pancreatitis - Pancreatic Ductal AdenoCarcinoma
Research Workgroup
DM-CP-PDAC
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Purpose:
Research working groups are a valuable platform for scientists with common research interests to collaborate and share knowledge.
These groups consist of staff members from various institutes and centers assembled by the consortium Steering Committee leadership. They provide input from their respective perspectives. Co-chairs, typically institute or center directors or senior staff, lead these working groups with the authority to approve major activities and funding actions.
These working groups are crucial in advancing scientific research, fostering collaboration, and promoting innovation across various fields of cancer research.
Objective:
The general hypothesis underlying the DETECT study is that hormone and glucose excursions measured during a mixed meal test can distinguish patients with new onset PDAC-DM and/or CP-DM from patients with T2DM. For the purposes of this study, new-onset diabetes is defined as diabetes that has developed within the preceding 36 months. Our primary objective is to test the hypothesis that the relative change in PP levels at 30 minutes following meal stimulation will be significantly lower (defined a priori as 20% lower) in the PDAC-DM and CP-DM groups compared to T2DM. Secondary objectives include additional comparisons across the same groups regarding insulin, glucagon, and incretin hormone responses.
Study Goals:
The goal of the study is to recruit a total of 452 subjects with PDAC, chronic pancreatitis, and no structural pancreatic disease (Table 2) at 9 participating clinical centers. Control subjects will be considered to have “no structural pancreatic disease” in the absence of clinical, laboratory, and/or imaging data to support the diagnosis of a pancreatic disorder (i.e., chronic pancreatitis or PDAC). Eligible subjects will be approached through a variety of methods, including participation in other related clinical studies performed by the CPDPC.
Alexandria Reyes
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Anupam Gaonkar
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Casey McClurkin
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Casi Bell
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Eric Carlson, CFA, MBA
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Eva Lustigova
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Eva Shrader
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Eve Karloski
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Gina Mercouffer
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Hannah Parks
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Jenny Chang
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Kari Chaffee
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Kerry Peterson
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Lynn Matrisian
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